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Clinical studies in humans have not been published so far ( Development, preclinical, and early clinical data on the GIP/GLP-1 receptor agonist tirzepatide Among the GIP/GLP-1 receptor agonists, tirzepatide (LY3298176) is the compound that is the most advanced in development and the first substance in this class that has received approval for the therapy of T2D by the FDA in May 2022 (manufacturer Eli Lilly Comp., trade name Mounjaro ) ( Pharmacodynamics Tirzepatide is a GIP/GLP-1 chimeric peptide with a peptide chain length of 39 amino acids
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However, several researchers are currently developing oral GLP-1 agonists for treating type 2 diabetes and obesity
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10.1007/s12640-022-00563-x Neurotox
