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This peptide is the active ingredient in the topical copper peptides that have been sold as cosmetic agents on the dermatology shelf since the late 1980s, with the caveat being that topical GHK-Cu needs to penetrate the stratum corneum layer of skin before getting to the dermis, which houses the receptors for the peptide

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The evidence for sublingual being substantially better than oral is mixed, but there is enough clinical experience supporting it in post-bypass patients that I think it is a sensible choice for that group