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doi: 10.1093/jexbot/53.372.1283 52 NoctorG.MhamdiA.ChaouchS.HanY.NeukermansJ.Marquez-GarciaB.et al

7,77 Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a common complication in which one or more of the following occur due to the loss of proper regulation by the kidneys: Abnormal bone mineralization, strength, growth, and turnover Calcification of non-bone tissues, including blood vessels Irregularities in vitamin D, calcium, phosphorus, fibroblast growth factor-23, and parathyroid hormone metabolism Each of these abnormalities is associated with a high risk of mortality, primarily attributable to the cardiovascular consequences

Institute of Stomatology & Oral Maxilla Facial Key Laboratory, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, China

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The members of the neurotrophin family of growth factors, such as BDNF and NGF, play essential roles in the development of the nervous system, as they support the survival, growth, and maintenance of neurons in the brain [229]