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According to a study in JAMA, tirzepatide resulted in more significant weight reduction

doi:10.1016/S0021-9258(18)46868-8

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Parkinsons, Alzheimers and other researchers are embedding nanoparticles of drugs in a substance called chitosan (a biodegradable, biocompatible polymer) which can adhere to mucous membranes in the nose and release much more of the drug much deeper into the brain than aerosolized preparations do

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