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Oleic acid, when it reaches the small intestine, converts into oleoylethanolamide (OEA), a lipid compound that activates a brain area responsible for greater feelings of satiety

In the landmark study that introduced it, published in Cell Metabolism (Lee et al., 2015), researchers showed that MOTS-c regulates insulin sensitivity and metabolic homeostasis through the AMPK pathway, and that treatment prevented diet-induced obesity and insulin resistance in animal models

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