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Call NHS 111 or seek same-day medical advice from your GP or diabetes specialist if you experience: Widespread rash covering large areas of the body Severe itching that significantly affects daily activities or sleep Blistering, peeling skin, or painful lesions Rash accompanied by fever, joint pain, or feeling generally unwell These symptoms may indicate a hypersensitivity reaction or other serious adverse effect requiring prompt assessment

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However, some patients experience diminishing returns or gastrointestinal side effects that prevent comfortable dose escalation

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