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Consistently, T3 treatment had similar effect on total percentage of TGR5-agonistic BAs in the ileum of mice in the euthyroid state, which could be abolished in LTRKO mice (Supplementary Fig

Any combination approach would be considered experimental and would require careful medical supervision and monitoring

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Suppression of food and water intake by GLP-1 mainly involves interactions with various hypothalamic nuclei, particularly the arcuate and paraventricular nucleus, as well as some hindbrain structures such as the parabrachial nucleus [31]

54 and Hes et al