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Diarrhea, abdominal pain, and decreased appetite (beyond what is therapeutic) round out the most frequently reported GI effects

Approximate doses per vial 40.0 doses Math reference only for in-vitro and laboratory research use

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(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

Supplementary Video 1 Partial unbinding and binding simulation of Ex4-l-Ala