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medRxiv 2026, IQVIA PharMetrics cohort (n=20,504 non-diabetic weight-loss users), incident allodynia 35 vs 15 per 1,000 person-years against bupropion-naltrexone, adjusted HR 2.15 (95% CI 1.572.96)

doi: 10.3390/ani13193104 137 ShengSHanNWeiYWangJHanWXingBet al

When cellular DNA damage occurs due to either endogenous or exogenous factors, genomic instability occurs, which may result in cancer development and an increased rate of cellular aging

Use with caution in patients with severe kidney disease or seizure disorders under medical supervision

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It also improves retention on a reversed-phase column, so standard chromatography suits it well