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The increase of NAD + levels by supplementation with precursors such as NR improves mitochondrial and muscular function and the function of neuronal cells in mice (Mendelsohn and Larrick, 2017)

Whilst vitamin B12 toxicity is exceptionally rare due to its water-soluble nature, very high levelsparticularly from mega-dose supplements or frequent injectionshave been associated with certain adverse effects, most notably skin reactions

Benzyl alcohol acts as a bacteriostatic agent, inhibiting the growth of microorganisms in the solution once the vial is opened