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Strategies to mitigate lean muscle loss while on treatment include optimising dietary protein, recognising that GLP-1 and GIP/GLP-1 receptor agonists may suppress appetite and substantially reduce overall energy intake, increasing the risk of inadequate protein consumption.260-262 Regular resistance exercise training can help preserve lean muscle mass during weight loss and should be performed on two or more days per week, where clinically appropriate.159 Dietary advice for people on incretin-based medications Incretin-based medications increase the risk of muscle loss, sarcopenic obesity and nutrient deficiencies

Liraglutide 3.0 mg reduced BMI by 4.3% over 56 weeks in adolescents with obesity, while placebo reduced BMI by 0.3% in the long term [115]

Yet in practice, they produce completely different outcomes for completely different purposes, and choosing the wrong one means months of wasted effort targeting the wrong mechanism entirely

Important safety warnings: Do not use if you have a salicylate allergy, are taking anticoagulants/antiplatelets, have bleeding disorders, or kidney disease

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