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Key findings included: in GIPR, the E/D7.42bA mutation reduced retatrutide potency by 71.6-fold and R196 ECL1 Y reduced potency by 107.7-fold

Research from that same physiology paper found that semaglutide reduces the appetite feedback parameter to 49 kcal per day per kilogram of weight loss, compared to 82-83 kcal per day per kilogram during calorie restriction alone

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Shaffer PL, Jivan A, Dollins DE, Claessens F, Gewirth DT