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In patients with cardiovascular diseases, clinical observations have demonstrated enhanced benefits of GLP-1RAs in treating prostate cancer

NCI 1R01CA193842-01, 1R01CA193842-06A1, 5R01CA186702-07, 1R01DK1010989-06A1, R01HL135564 and R01CA225231-01

Zhihong Y, Chen W, Qianqian Z, Lidan S, Qiang Z, Jing H, et al

The underlying mechanism involves AS-IVs ability to reduce mitochondrial ROS in myocardial cells of MI mice, inhibit NLRP3 inflammasome activation, and subsequently downregulate the expression of downstream inflammatory factors such as IL-18 and IL-1, along with the caspase-1 regulator involved in cell pyroptosis

Multiple systematic reviews and meta-analyses have been conducted, with most indicating no significant difference in fracture risk between GLP-1Ra and placebo or other anti-diabetic medications [75,76,77]

This isnt necessarily the case for compounded GLP-1s