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The oral-contraceptive interaction is a separate study (GPGR), reported in the FDA Mounjaro NDA 215866 summary review: a single 5 mg tirzepatide dose with a combination oral contraceptive (0.035 mg ethinyl estradiol / 0.25 mg norgestimate) reduced the Cmax of norelgestromin and ethinyl estradiol by 55% to 59% a range spanning both analytes, not a separate figure for each with AUC lowered 28.8% (norelgestromin) and 27% (ethinyl estradiol), and tmax delayed 2.5 to 4.5 hours
Dec 1 2016;66(4):449-469
This article is for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment
FDA has not issued a final determination and has not announced a timeline
(6) The liver and kidneys shape the number further
To convert either of these into a per-user schedule and cost, use the dosage calculator
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