Over time, insulin resistance can become type 2 diabetes, as the body produces even more insulin to lower blood sugar
However, the lack of extensive human clinical trials means long-term safety data in humans remains limited
That includes proactive management of side effects, candid conversations about the long-term nature of treatment, infrastructure to identify and support patients at risk of stopping and addressing the cost barriers that make GLP-1 therapy unsustainable for many. These measures are especially important, Al-Aly noted, because the cardiovascular protection provided by GLP-1 medication builds slowly, but it erodes quickly
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Since the peptide is naturally available in the body, it rarely causes irritation
References Arjinpathana N