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The most robust clinical evidence arguably originates from the large cardiovascular outcomes trials (CVOTs) completed for most GLP-1 RAs, of which the latest showed a significant relative risk reduction (RRR) of 39% (HR) with once-weekly efpeglenatide on HF requiring hospitalisation, corroborating a meta-analysis which found a significant RRR across eight GLP-1 RA CVOTs of 11%

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BPC-157 for 46 weeks or longer if needed 3

With GSH depleted, TCR signal transduction is blunted, reducing T-cell proliferation and protective cytokine output

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