Drug Targets 15 (4), 390402
Underexplored peptide systems may struggle to compete directly with GLP-1-based therapies unless they offer clear advantages, such as improved tolerability, complementary mechanisms, or benefit in patient populations poorly served by existing drugs
Greff D, Juhsz AE, Vncsa S, et al
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It is widely hypothesized that dysfunction in various components of the glutamate-GABA system contributes to neurodevelopmental and neurodegenerative disorders ( 1,2 Regional and circuit-specific dysfunction resulting in an excitatory-inhibitory imbalance is believed to contribute to these disorders based on the location of the dysfunction and the temporal onset of the imbalance