The primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which helps lower blood glucose levels without causing hypoglycaemia when used alone [17] [18] Suppressing glucagon release from pancreatic alpha cells, reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces postprandial glucose excursions Reducing appetite through central nervous system pathways, particularly in the hypothalamus, leading to decreased caloric intake and weight loss It's important to note that while GLP-1 receptor agonists have a low risk of hypoglycaemia when used alone, this risk increases when combined with insulin or sulfonylureas
These treatments support faster healing and enhance immune function, reducing the risk of infection and other complications that can delay recovery
One study reported that somatostatin does not suppress insulin secretion by acting on the central nervous system but acts peripherally on islet beta-cells
(1) J Ishida, M Saitoh, N Ebner, J Springer, et al (2020) Growth hormone secretagogues: history, mechanism of action, and clinical development JCSM Communications, Volume 3, Issue 1, January/June 2020, Pages 25-37
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Oleh karena itu, menjaga kadar glutathione yang sehat merupakan strategi penting untuk memperkuat daya tahan tubuh