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To confirm the metabolic effects are on-target, PL7737 was administered twice-daily to DIO and Mc4r KO mice at 30 mg/kg over five days (137)
The ads signal that GLP-1 drugsoriginally developed to treat type 2 diabeteshave become household names
Subsequently, multiple large outcome trials of SGLT2is have demonstrated a reduction in all-cause mortality and hospitalisation for heart failure in patients with HFrEF [20] and HFpEF [21], irrespective of diabetes status
Takeaway: The single best thing you can do is start high-protein eating and appropriate supplementation on day one of GLP-1 therapydont wait until you notice shedding
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None of the patients from the case series was rechallenged with GLP-1 RAs due to safety concerns
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