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It initiates rapid repair by enhancing keratinocyte and fibroblast migration, stimulating angiogenesis, and restoring tissue integrity

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However, viruses can exploit this process: ZIKV induces mtDNA leakage while simultaneously inhibiting STING activation, skewing the immune response ( Cytochrome c release, a hallmark of mitochondrial outer membrane permeabilization, activates the intrinsic apoptotic pathway via caspase-9 activation

Microcolony formation follows, with bacterial proliferation and matrix development

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