Of those who had taken the drugs, more than 40% said the drugs had been prescribed for diabetes
Because outcome reporting varied across studies, a prespecified harmonization strategy was applied before quantitative synthesis
JCI Insight 8 , e164921 (2023)
Unfortunately, we also found that GLP-1 drugs come with significant side effects and increase the risk of 19 health conditions we studied, such as gastrointestinal issues, kidney stones and acute pancreatitis, in which the pancreas becomes inflamed and dysfunctional
Plus, it stops the production of glucagon , thus decreasing glucose from the liver
These modifications allow researchers to investigate receptor-mediated signaling over extended experimental timeframes while maintaining consistent ligand-receptor interactions under controlled laboratory conditions