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Due to decreased cardiolipin metabolism, melanocytes from vitiligo patients have low energy production from glycolytic phosphorylation (due to defects in complex 1), resulting in low ATP production and high mitochondrial ROS production (Figure 2

doi: 10.1007/s00210-025-04394-3 2 GonfaYHBachhetiASemwalPRaiNSingabANBachhetiRK

Glutathione peroxidase 1 Glutathione peroxidase 1 , also known as GPx1 , is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3

Functional antioxidant responsive elements

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Arbutin : Reduces melanin production, helping to fade dark spots and pigmentation