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Importantly, GLP-1 receptor agonists are not indicated for type 1 diabetes or diabetic ketoacidosis, and should not be co-prescribed with DPP-4 inhibitors (such as sitagliptin or linagliptin)
These large-scale studies have generally demonstrated favourable cardiovascular profiles, with some agents showing significant reductions in major adverse cardiovascular events (MACE) in patients with type 2 diabetes and established cardiovascular disease
They have also stimulated a pipeline of follow-up injectable and oral drugs, as other companies attempt to enter a lucrative market, while Novo and Lilly seek to reinforce their positions as market leaders
single-use autoinjectors (like Trulicity and Wegovy) typically do not require bubble removal or priming
It is important to note that individual responses vary considerably
