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Experimental models investigate how integrated incretin and glucagon signaling contributes to broader regulatory systems governing energy balance, substrate utilization, hormonal communication, and adaptive metabolic responses

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Adults with a body mass index (BMI) of 30 or greater Adults with a BMI of 27 or greater who also have one weight-related condition, such as type 2 diabetes, high blood pressure, or high cholesterol Wegovy and Saxenda are also approved for the treatment of children age 12 and older

In addition, GLP-1 medications target areas of the brain that regulate appetite and food cravings

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