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GLP-1RAs appear to offer a potential dual therapeutic advantage, simultaneously targeting metabolic dysfunction and immune-mediated inflammation, thereby representing a potentially promising strategy in the management of early-stage PsA early PsA, although robust clinical evidence in this setting is currently lacking
Neither option is ideal, and both leave money on the table that could be saved with the right payment strategy
2025 Jul 3;393(1):26-36
Real-world UK data from the STRIVE study - a multicentre randomised controlled trial across specialist weight management services in the UK and Ireland - found that 21% of participants on a structured liraglutide pathway achieved more than 15% weight loss at one year
however, their direct effects on distal organs, including the penis, have not been conclusively demonstrated in human studies (74, 75)
If any step breaks down (low stomach acid, lack of intrinsic factor, or gut inflammation), much of the B12 passes through unabsorbed
