Moreover, tumours did not show signs of oxidative stress or compensatory metabolic changes, such as accumulation of cysteine (Extended Data Fig
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In addition to the results from SURPASS 4, which was designed to provide preliminary evidence for the cardiovascular safety of tirzepatide, a separate analysis pooling all the clinical trials with tirzepatide was used to generate a pre-specified estimate of cardiovascular events [20] (Table 1)
Dose it preventively, use a bioavailable form, and recognize it as one tool in a broader strategy that includes hydration, pacing alcohol intake, and eating before drinking
Trial populations, comorbidities, and endpoints varied across the studies, and individual results differ
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