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UCP1 is expressed in brown adipose tissue (BAT), UCP2 is expressed in a number of tissues such as the intestines and adipose tissue, while UCP3 is expressed in skeletal and heart muscle

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Results indicate that good oral absorption is more likely with drug molecules that have less than 5 hydrogen bond donors (defined as NH or OH groups)/10 hydrogen bond acceptors (defined as oxygen or nitrogen atoms, including those that are part of hydrogen-bond donors), a molecular weight that is smaller than 500, and a calculated lipophilicity (cLog P) that is smaller than 5 (Lipinski 1995, Lipinski 2000, Lipinski et al

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