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Final Thoughts Semaglutide and Tirzepatide aren't just weight loss medsthey're powerful metabolic tools that can transform life with PCOS

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doi:10.1136/bmj-2025-085304 6

Phase 2 data published in 2023 reported mean body-weight reductions of up to 24.2% at 48 weeks on the highest dose tier (Jastreboff et al., NEJM 2023)

The derivation from native hGH provides biological plausibility: the C-terminal region of growth hormone has been known since the 1990s to possess independent lipolytic activity separate from the growth-promoting effects mediated by intact GH and IGF-1 signaling