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Extremely high plasma glycine concentrations may lead to hyperglycinemia and, via catabolism, hyperammonemia, potentially causing neurological symptoms such as headache or confusion-though such events are exceedingly rare outside massive irrigant absorption

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What to avoid while taking methylene blue If you consume methylene blue, avoid food and drinks rich in tyramine

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Intravenous and intramuscular administration bypasses the digestive system, which metabolizes the substance and sends only a portion to cells