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When to contact your prescriber Contact your prescribing team if you experience: Severe or persistent nausea, vomiting, or diarrhoea that is affecting your ability to eat or drink Severe abdominal pain, particularly if it radiates to the back Signs of an allergic reaction, including facial swelling, difficulty breathing, or a severe rash No change in appetite or weight after four or more weeks on a stable therapeutic dose Do not adjust your dose or stop treatment without speaking to your prescriber first