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Research presented at the 2025 American Academy of Orthopaedic Surgeons meeting found GLP-1 users had approximately 30% higher rates of osteoporosis compared to non-users, and a 2024 phase 2 trial published in eClinicalMedicine showed increased bone resorption markers and lower bone mass at the spine and hip in the semaglutide group versus placebo after 52 weeks

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Singh added that results from the ongoing FOCUS studya long-term ophthalmic endpoint trial evaluating semaglutide versus placebo in patients with type 2 diabeteswill be critical in clarifying the long-term retinal safety profile of GLP-1 therapies

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Weight regain after stopping medication is common, with many patients regaining 50-100% of lost weight within a year

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