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SMP reverses the GDHS metabolic phenotype by rescuing core metabolic pathways After a standardized 4-week therapy with SMP, PCA analysis demonstrated a significant shift in the post-treatment metabolic profile toward the HC group, indicating that SMP effectively reversed the systemic metabolic disturbances induced by GDHS (Fig

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These changes resulted in hippocampal cell loss, decreased internal memory, and basal forebrain cholinergic neuron atrophy (Fernandes et al., 2021)