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In rare instances, this may cause small tears in the oesophageal lining (Mallory-Weiss tears) or irritation to the gastric mucosa, potentially resulting in haematemesis (vomiting blood) or melaena (dark, tarry stools indicating upper gastrointestinal bleeding)

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Oral semaglutide has been shown non-inferior to daily liraglutide injection, and to have significant A1c lowering and weight loss when compared to SGLT2 empagliflozin and DPP4 sitagliptin

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Tirzepatide : Some patients have experienced up to a 20% reduction in body weight over 88 weeks