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Muscle mass loss: Multiple studies confirm that a significant portion of weight lost on GLP-1 drugs is lean muscle, not fat

In addition, as this study was observational, prospective studies with standardized neuropsychiatric assessments are needed to confirm these associations

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The moral of the story is, semaglutide may improve leptin sensitivity by regulating leptin and preventing resistance to this powerful satiety hormone

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The gap between animal promise and human confirmation is significant and should inform realistic expectations