Systemic effects from retatrutide's mechanism: Based on the GLP-1/GIP/glucagon receptor class, potential adverse effects include nausea, vomiting, diarrhoea, reduced appetite, and gastrointestinal disturbance
The phase 2 trial was too small to detect rare events
Safety and Tolerability of GLP-1, Dual, and Triple Agonists in Adolescents While GLP-1RAs and their dual and triple agonist counterparts have shown remarkable efficacy in weight loss and metabolic control, their safety and tolerability profiles remain key concerns, especially in adolescent populations
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doi: 10.1111/eip.13149 121 NieL
A major programme of works carried out before that year enhanced the historic aesthetics of an entire sector of the central medina