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A study of National Health and Nutrition Examination Survey (NHANES) found that serum iron, total iron-binding capacity, and transferrin saturation were lower in people with DKD,albuminuria, and reduced eGFR

In an antimicrobial context, this could tentatively be interpreted as ApoE playing a role in coordinating metal ions to alter A aggregation dynamics toward increased cytotoxic aggregate formation to increase As antimicrobial efficacy (either alone or in synergy with other AMPs and copper), for which ApoE4 might exert the strongest synergistic AMP effect due to its copper-A interaction and its ability stabilize cytotoxic A oligomers/fibrils (Garai et al., 2014)

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Peptides are short chains of amino acidsessentially, tiny proteins your body already produces

Xu JJ, Cui J, Lin Q, Chen XY, Zhang J, Gao EH, et al