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They may be acting on one of the upstream drivers of neurodegeneration directly

Initial human tissue analysis revealed that FOXO4 is specifically expressed within Leydig cells of the human testis, as confirmed by its co-expression with Leydig cell markers StAR and CYP11A1 through immunofluorescent staining

After 48 h, blood was taken and the kidneys were removed and processed as described above (Supplementary Fig

These medications arent a shortcut

This work was supported by Basic Scientific Research Fund of Education Department of Liaoning Province, China (LJ212410161100 to Z-LL), Natural Science Foundation of Liaoning Province, China (2022-MS-326 to Z-LL), and Dalian Medical University's "Integrated Traditional Chinese and Western Medicine " Open Fund Project (ZXY2025JC04 to Z-LL)

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