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Although cholecystitis has been reported, large outcome trials have not substantiated pancreatitis signals, and current evidence does not indicate increased risks of infection or obesity-related cancers
The concern is that cancers can sometimes exploit some of these same pathways to grow, spread, or build their own blood supply
Conversely, while broad-spectrum PHD inhibitors (e.g., Roxadustat [489]) promote erythropoiesis to treat anemia, their potential pro-oxidant side effects also require careful evaluation, reflecting the dual nature of intervention strategies
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