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Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice
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10.1186/s12951-023-01862-x 111 WangZ.LiM.LiuY.QiaoZ.BaiT.YangL.et al (2021)
Mechanistically, UFL1 UFMylates AKT1 at lysines (K) 189, K276, and K297, disrupting the interaction between the PH domain and KD (kinase domain) of AKT1, thereby facilitating AKT1 localization at the ER and subsequent phosphorylation at T308 and S473 by PDK1 and mTORC2, respectively
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