Understanding this interaction can open up new avenues for treatments aimed at preventing or modulating eryptosis to improve AKI management, with particular attention to CRRT techniques that may be applied in severe cases
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up to 10 mM in liver the most abundant non-protein thiol in mammalian cells Redox forms: Reduced GSH (active) and oxidised GSSG
But theres a catch with that too (more on that later)
Compared with disulfide-based systems, which are widely used due to their simplicity and predictable cleavage by intracellular GSH, diselenide linkages offer greater redox sensitivity and can respond to both GSH and ROS
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