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Richman PG, Meister A

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of -ketoglutarate-dependent dioxygenases

What the clinical trial evidence shows Mounjaro (tirzepatide) ~22.5% average body weight lost at 72 weeks ( SURMOUNT-1, 15mg) Wegovy (semaglutide) ~14.9% average body weight lost at 68 weeks ( STEP-1 , 2.4mg) Saxenda / Nevolat (liraglutide) ~5-8% average body weight lost at 56 weeks ( SCALE trial ) For context, prior to GLP-1 medications, the most effective non-surgical weight loss intervention available was a combination of intensive lifestyle modification and Orlistat , which typically produces 5 to 8% weight loss

Many other factors could explain the results

Bacterial growth without the benzyl alcohol preservative rapidly contaminates the solution and can introduce infection risk

The practical consequence for an experiment is that ipamorelin is the appropriate tool when you want to interrogate GH release without a confounding stress-axis response