tirzepatide in bodybuilding to obesity (~300lbs) to now on (-66lbs, to ~231lbs, 163cm) : r/Zepbound Life lately on a low

Gulati said common side effects of the drug are nausea and constipation

Gut microbiota dysbiosis increases the risk of visceral gout in goslings through translocation of gut-derived lipopolysaccharide

Source: Jastreboff et al., NEJM 2023 TRIUMPH-4 Phase 3 (68 weeks, 445 participants) Phase 2 Type 2 Diabetes Trial (36 weeks, 281 participants) In the type 2 diabetes population, weight loss was lower than in the obesity trial which is consistent with the pattern seen across all GLP-1 drugs

Still, we know little about how it interacts with prescription medications like blood thinners or seizure medication

Some notice mild nausea during the first 2 to 3 days after the initial injection

Figure 4 Indeed, requiring FAD as coenzyme, methylenetetrahydrofolate reductase (MTHFR) is responsible for the formation of 5-methyltetrahydrofolate