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Until we have larger, more definitive studies, the safest approach is still to stop GLP-1 medications before trying to conceive. The findings, however, are exactly the kind of data we need to justify properly designed prospective trials, says Lora Shahine, MD, a reproductive endocrinologist and obstetrician-gynecologist at PNWF IVY Fertility Center in Bellevue, Washington, and host of the Brave and Curious podcast
The small number of outcome events in this study, which recorded only 70 events among 25,617 users of GLP-1RAs and had only 6,622 patients on GLP-1RAs remaining two years after cohort entry, has limited statistical power
References Dhakal A, Sbar E