The proposed mechanisms underlying these protective effects include the inhibition of several signaling pathways implicated in cancer initiation and progression, such as the phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR), extracellular signal-regulated kinase/microtubule-associated protein kinase, and nuclear factor kappa-light-chain-enhancer of activated B cell pathways [32-34]
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The glucagonostatic characteristics of GLP-1 RA could prove to be more relevant to individuals with beta cell deficiency [51] which contrasts with type 2 diabetes where beta cell dysfunction and impaired incretin effect may dominate [52]
Mitchel P