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Dysbiosis, or an imbalance in gut microbiota, is associated with metabolic diseases, especially T2DM, and can cause changes in the signaling pathways of intestinal hormone secretion, leading to various health problems [156]
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Emerging evidence delineates central roles of GLP-1 in appetite regulation, neuroprotection, neuroinflammatory mitigation, enhanced intracellular signaling, and cognitive enhancement 72,73,74
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Cell cycle-dependent control of homologous recombination
Oxidative stress associated with cardiovascular disease oxidizes BH 4 , so the administration of additional BH 4 under such conditions may further decrease the BH 4 /BH 2 ratio
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