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Giovannucci, C
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It is postulated that DM-induced oxidative damage may be more significant in erythrocytes than in other cells, due to their high content of iron and polyunsaturated fatty acids, as well as their role as oxygen transporters, with a high degree of exposure to free radicals [320]
Solute carrier family 1 member 1 (SLC1A1) was found to be a membrane glutamate transporter that functions to transport extracellular glutamate into the cell, driving SLC7A11-mediated cystine uptake [109]
Surprisingly, no difference between sg CBS and sgRNA controls was detected for intracellular cysteine or GSH levels (Supplementary Fig
There are no randomised controlled trials supporting their use in this condition, and patients should continue evidence-based therapies such as disease-modifying antirheumatic drugs (DMARDs) as recommended by NICE guidance
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