Tricyclic antidepressants, such as cyclobenzaprine are dosed at 520 mg or nortriptyline, initiated at a dose of 10 mg at bedtime, while SNRIs like duloxetine and venlafaxine are started at 30 mg and 37.5 mg daily, respectively, titrated to a maximum of 50% of that used in non-cirrhotic population
Fu LL et al
1991 May 8;57(2):91-4
In summary, GLP-1 RAs represent a promising therapeutic option for obese patients with HFpEF, but their large-scale adoption will require further evidence of efficacy, safety, and long-term benefits through rigorous and well-designed clinical trials
AOD 9604 is not associated with any adverse side effects
Eur J Endocrinol 153: 747-753 Duranay M, Akay H, Yilmaz FM, Senes M, Tekeli N, et al