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Absolute deficiency occur up to 6% of those aged 60 years and older, whereas marginal deficiency occur in close to 20% of patients in later life ( Pernicious anemia is an autoimmune gastritis resulting from the destruction of gastric parietal cells and consequent impairment of intrinsic factors secretion to bind the ingested vitamin B12

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It is composed of 15 amino acids in a very particular sequence that doesnt exist naturally

doi: 10.1186/s13045-019-0720-y 12 MaLChenCZhaoCLiTMaLJiangJet al