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Mod Pathol (2019) 33:84657

2010 Jul;33(7):32634

AgRP co-exists with neuropeptide Y (NPY) in neurons originating from the arcuate nucleus and are involved in interlinked control with the central POMC neurons, and with factors such as cocaine and amphetamine regulated transcript (CART), dopamine, leptin and insulin

This leads to higher insulin levels, which can promote fat storage, particularly in the abdominal area

5 Evidence indicates that patients with TED produce autoantibodies that stimulate this receptor complex, causing hyperactivation of orbital fibroblasts and immune cells which mediate the disease process in susceptible individuals

Increasing protein intake during the luteal phase helps manage hunger and preserve lean muscle mass