I would frame these findings as hypothesis-generating and clinically important, but not definitive proof that GLP-1 therapy directly caused the reductions we observed, Sheer says
In order to improve fiber intake during a caloric deficit with reduced appetite, prioritizing the highest-fiber food sources (avocado, chia seeds, pears, berries, legumes) alongside fiber supplementation will help to mitigate the constipation experienced with GLP-1 agonists while supporting the therapeutic goal of satiety and blood glucose regulation
S.YangH
Derived from a protein sequence naturally present in gastric juice, this synthetic 15-amino acid peptide now sits behind more than 500 published studies spanning a wide range of tissue and organ models, making it one of the most heavily researched regenerative peptides in the field (Vasireddi et al., 2025)
C.DuncanM
22 In the PIONEER-6 trial evaluating oral semaglutide, among patients with T2DM, the CV risk profile was not inferior to that of patients in the placebo group but it did not show superiority of this agent to placebo